Computer simulations to engineer PDZ-peptide recognition / Simulations numériques pour le dessin des interactions PDZ : peptide
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APA-like:
Tác giả chưa xác định. Computer simulations to engineer PDZ-peptide recognition / Simulations numériques pour le dessin des interactions PDZ : peptide. Thesis, HAL - Pháp.
Việt Nam (chuẩn TCVN 5453:1991):
. Computer simulations to engineer PDZ-peptide recognition / Simulations numériques pour le dessin des interactions PDZ : peptide. Thesis. HAL - Pháp. Truy cập từ .
Tóm tắt
Protein-protein interactions (PPIs) regulate complex signaling networks in eukaryotic cells. Many binding events between several protein domains transfer information through communication pathways. Disrupting or altering the equilibrium between PPIs plays an important role inseveral diseases and the inibition of targeted PPIs is a recognized strategy for computational drug design. In the present thesis we focused on PDZ domains, which are among the most widespread signaling domains. PDZs recogni...